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McInnes, Campbell
One or more keywords matched the following items that are connected to McInnes, Campbell
Item TypeName
Academic Article Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Academic Article Calpain 10 homology modeling with CYGAK and increased lipophilicity leads to greater potency and efficacy in cells.
Concept Models, Molecular
Academic Article Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange.
Academic Article Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.
Academic Article Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors.
Academic Article Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes.
Academic Article Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design.
Academic Article Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.
Academic Article Protein structures in virtual screening: a case study with CDK2.
Academic Article Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design.
Academic Article Structure-based discovery and optimization of potential cancer therapeutics targeting the cell cycle.
Academic Article Improved lead-finding for kinase targets using high-throughput docking.
Academic Article Catch the kinase conformer.
Academic Article Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance.
Academic Article Functional characterization of the RAD51D E233G genetic variant.
Academic Article Non-ATP competitive protein kinase inhibitors as anti-tumor therapeutics.
Academic Article Design, synthesis, and evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors.
Academic Article Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.
Academic Article Structural and functional analysis of cyclin D1 reveals p27 and substrate inhibitor binding requirements.
Academic Article Optimization of non-ATP competitive CDK/cyclin groove inhibitors through REPLACE-mediated fragment assembly.
Academic Article Structural characterization of the binding interactions of various endogenous estrogen metabolites with human estrogen receptor a and ? subtypes: a molecular modeling study.
Academic Article Iterative conversion of cyclin binding groove peptides into druglike CDK inhibitors with antitumor activity.
Academic Article Synthesis and biological evaluation of ranitidine analogs as multiple-target-directed cognitive enhancers for the treatment of Alzheimer's disease.
Academic Article Peptidomimetic design of CDK inhibitors targeting the recruitment site of the cyclin subunit.
Academic Article Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop.
Academic Article A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics.
Search Criteria
  • Models Molecular